Purpose: To explore National Survey of Pharmacy Practice at MOH hospitals in Saudi Arabia 2016-2017: Preparation of medications and Dispensing. Methods: It is a 4-months cross-sectional National Survey of Pharmacy Practice at MOH hospitals in Saudi Arabia. The study consisted of two parts; the demographic information and the second part contained eighty-five questions divided into nine domains drove from American Society of Health-System Pharmacists (ASHP) and Saudi Pharmaceutical Society (SPS) survey, the international standard of Joint Commission of Hospital Accreditation. An electronic questionnaire was distributed to 185 directors of pharmacies at MOH hospitals. The study discussed and analyzed National Survey of Pharmacy Practice at MOH hospitals in Saudi Arabia 2016: Preparation of medications and Dispensing. All analysis is done through survey monkey system. Results: The survey was carried out in 185 hospitals, the rate of reply was 105 (56.75%). The pharmacy services were the drug distribution unit dose 36 (34.3%), repacking operation system 15 (14.3% %), an extemporaneous preparation 22 (21 %), and Intravenous admixture 8 (7.6%) only. The drug distribution by unit dose commonly not existed at the hospital less than 100 beds size 18 (17.14). The Intravenous admixture commonly found at 200-400 beds hospitals 6 (5.7%). The hospital home infusion therapy provided from six (5.7%) hospital pharmacies only. The most outpatient prescriptions dispensed to hospital employees 69 (65.7%) hospital clinic or patients discharged or emergency room 63 (60 %), general public 58 (55.2%), and home healthcare services 31 (29.5%). The most system founded to assure the accuracy of preparations and dispensing. One pharmacist check drug order before dispensing 48 (45.7%), and two pharmacists review high-risk drugs 28 (26.7%) at all type of hospitals bed size. Conclusion: The essential elements of pharmacy, the cost, and improve outcomes associated with drug therapy care of patients as a member of the multidisciplinary care team. [5,6,7] To Provide PC; pharmacists should supply the knowledge of clinical pharmacy and best skills. In Saudi Arabia, PC practice is still improving. In a study of Al-Arifi et al. showed that practice was weak at MOH hospitals. Annual survey of pharmacy services with improving drug distribution system prevent drug-related problem and improve patient care at Hospitals in Saudi Arabia.