Published on:October 2017
    Journal of Pharmacy Practice and Community Medicine, 2017; 3(4):220-224
    Research Article | doi:10.5530/jppcm.2017.4.63

    Effects of 6-Week Micronutrient Supplementation on Sperm Parameters and Pregnancy Outcomes in Males with Idiopathic Infertility Undergoing Fertility Interventions: A Pilot Cohort Study

    Authors and affiliation (s):

    Choo Gim Sun1*, Aw Lin Da2, Ooi Bee Sen2, Zamri Yusof2, Huan-Keat Chan3, Kathirgamanathan Balanathan4, Murizah Mohd Zain2

    1Obstetrics and Gynaecology Department, Penang General Hospital, Jalan Residensi, 10990, Pulau Pinang, MALAYSIA.

    2Reproductive Unit, Obstetrics and Gynaecology Department, Sultanah Bahiyah Hospital, Alor Setar, Kedah, MALAYSIA.

    3Clinical Research Centre, Sultanah Bahiyah Hospital, Alor Setar, Kedah, MALAYSIA.

    4Department of Obstetrics and Gynaecology, Seberang Jaya Hospital, Penang, MALAYSIA.


    Objective: To evaluate the effectiveness of the consumption of Profortil®, a combination of eight micronutrients, on sperm count, sperm motility, and pregnancy outcomes following a fertility intervention among infertile males in Malaysia. Methods: A cohort study was undertaken at the Seberang Jaya Hospital and the Sultanah Bahiyah Hospital, Malaysia. A total of 90 infertile males were enrolled, 52 of which decided to take two capsules of Profortil® daily for a six-week period during 1st September and 30th November 2016. Those who decided not to consume Profortil® served as the control group (n=38). Semen analysis and an observation of pregnancy outcomes following the fertility interventions were conducted after 6 weeks. Results: Despite the consumption of Profortil®, both groups showed a significant increase in sperm count (p<0.001), but no change in sperm motility after 6 weeks. Although the difference in increment of sperm count between two groups was not significant, more participants who took Profortil® achieved a sperm count above 15 million/mL (25% versus 18.4%). The Profortil® group also demonstrated a higher pregnancy rate following the fertility interventions (26.9% versus 18.4%). Conclusion: The findings suggest that Profortil® could be helpful in improving the sperm parameters and pregnancy outcomes. Nevertheless, to optimize its effectiveness, a longer supplementation duration is likely to be needed.

    Key words: Micronutrient Supplementation, Sperm count, Oligospermia, Male infertility, Pregnancy outcome