@article {79,
	title = {A Case Report on Bupivacaine Induced Limb Weakness; Type I  Augmented Adverse Drug Reaction (ADR)},
	journal = {Journal of Pharmacy Practice and Community Medicine},
	volume = {8},
	year = {2022},
	month = {May 2022},
	pages = {18-19},
	type = {Case Report},
	chapter = {18},
	abstract = {<p class="rtejustify">Bupivacaine is an amide-type, long-acting local anesthetic. It acts by preventing generation or conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold. Lower limb motor weakness is a well-known complication of epidural analgesia with local anesthetics. In this case report a 60yr old female developed Bupivacaine induced lower limb weakness post-surgery. This event was identified as Type 1 augmented ADR which was assessed and reported with the help of Naranjo ADR scale. The dose of Bupivacaine was reduced as per clinical pharmacist{\textquoteright}s suggestion and that helped in recovery from the weakness on the same day. Type 1 augmented ADR is related to the pharmacological action of the drug or due to the exaggerated pharmacologic response.</p>
},
	keywords = {ADR, Bupivacaine, Epidural analgesic, Limb weakness, Naranjo scale.},
	doi = {10.5530/jppcm.2022.1.5},
	author = {Jeffin Gloria John}
}
