@article {79, title = {A Case Report on Bupivacaine Induced Limb Weakness; Type I Augmented Adverse Drug Reaction (ADR)}, journal = {Journal of Pharmacy Practice and Community Medicine}, volume = {8}, year = {2022}, month = {May 2022}, pages = {18-19}, type = {Case Report}, chapter = {18}, abstract = {
Bupivacaine is an amide-type, long-acting local anesthetic. It acts by preventing generation or conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold. Lower limb motor weakness is a well-known complication of epidural analgesia with local anesthetics. In this case report a 60yr old female developed Bupivacaine induced lower limb weakness post-surgery. This event was identified as Type 1 augmented ADR which was assessed and reported with the help of Naranjo ADR scale. The dose of Bupivacaine was reduced as per clinical pharmacist{\textquoteright}s suggestion and that helped in recovery from the weakness on the same day. Type 1 augmented ADR is related to the pharmacological action of the drug or due to the exaggerated pharmacologic response.
}, keywords = {ADR, Bupivacaine, Epidural analgesic, Limb weakness, Naranjo scale.}, doi = {10.5530/jppcm.2022.1.5}, author = {Jeffin Gloria John} }