02369nas a2200229 4500008004100000245015400041210006900195260001800264300001000282490000600292520159400298653003501892653001601927653002001943653003601963653001801999653001502017653001902032100002202051700002102073856004502094 2021 eng d00aProbiotics and its Impact on Antibiotic-associated Diarrhea (AAD) and Clostridum difficile Infections (CDI) in Adult and Pediatric Patients: A Review0 aProbiotics and its Impact on Antibioticassociated Diarrhea AAD a cDecember 2021 a46-480 v73 a
A common adverse effect of antibiotic use is diarrhea. Probiotics are living micro-organisms, which may prevent antibiotic-associated diarrhea (AAD) by the normalization of an unbalanced gastrointestinal flora. The objective of this review was to assess the benefits and harms of probiotics used for the prevention of AAD in patients based on literature findings. Thus review of the literature using bibliographic databases and abstracting systems such as PubMed (1978- 2020) and Cochrane was conducted to find the effects of probiotics and compare AAD and CDI in both pediatric and adult populations and determine significant differences and similarities that might impact clinical decisions. In general, pediatric AAD and CDI have a more rapid onset of symptoms, a shorter duration of disease and fewer CDI complications (required surgeries and extended hospitalizations) than in adults. Literature studied revealed the finding that suggests that probiotic use in both adult and populations may be beneficial in the prevention of AAD among patients. Furthermore, the use of probiotics appears to be safe. The narrative review adds value to the current knowledge owing to the fact that adult and pediatric differences of AAD and CDi have not been studied in many review focusing on current evidence before ours. The differences in treatment modality across age groups should be taken into account when rating severity of disease and prescribing antibiotics. However, any differences should be taken into account when rating severity of disease and prescribing.
10aAntibiotic-associated diarrhea10aAntibiotics10aBifidobacterium10aClostridum difficile infections10aLactobacillus10aprobiotics10aSaccharomyces.1 aChakraverty, Raja1 aSasmal, Sudeshna uhttps://jppcm.org/article/2021/7/3/46-48