01510nas a2200193 4500008004100000245008000041210006900121260001600190300001000206490000600216520092600222653000801148653003401156653002401190653001801214653001601232100002301248856004501271 2022 eng d00aCase Series on Teicoplanin Induced Thrombocytopenia – An Issue of Concern0 aCase Series on Teicoplanin Induced Thrombocytopenia An Issue of cAugust 2022 a34-350 v83 a
Teicoplanin is a glycopeptide antibiotic which inhibits peptidoglycan polymerization in gram-positive bacteria resulting in their cell death. Thrombocytopenia is a blood disorder in which platelet count falls below 100,000 cells/μl. Bleeding occurs when platelet falls below 20,000 cells/μl. In this case series, three patients with different clinical scenarios are explained who developed thrombocytopenia associated with teicoplanin administration during their course of medication. They were identified, assessed and reported for the ADR with the help of Naranjo ADR probability scale. As far as to our knowledge teicoplanin induced thrombocytopenia is not much studied and reported. In a current emerging use of higher antibiotics like teicoplanin, this is a serious life-threatening condition that has to be carefully monitored while on treatment with these types of higher antibiotics.
10aADR10aDrug induced thrombocytopenia10aHaemolytic anaemia.10aNaranjo scale10aTeicoplanin1 aZS, Mohamed, Aamir uhttps://jppcm.org/article/2022/8/2/34-3502432nas a2200229 4500008004100000245008300041210006900124260001500193300001000208490000600218520172700224653002601951653002501977653001802002653001902020653002202039100002802061700001502089700003302104700002002137856004502157 2020 eng d00aIncidence and Assessment of Adverse Drug Reactions at a Tertiary Care Hospital0 aIncidence and Assessment of Adverse Drug Reactions at a Tertiary cApril 2020 a15-170 v63 aBackground: Adverse drug reactions have proved a significant problem in healthcare for decade. Healthcare professionals have a responsibility in use of rational drugs for their patients. Objectives: The aim of the study was to determine the prevalence of ADRs in a tertiary care hospital to determine the most common Therapeutic Class of Drugs causing ADR and to determine the most common Organ system affected by ADR. Methods: The Prospective, observational study was conducted in the wards of St. Philomena’s Hospital, Bangalore between January 2016 and August 2016. All In-patients were monitored for ADRs during their admission period. Results: Over the study period of 12 months, a total of 374 ADRs were reported in 600 patients. The ADRs observed were higher in female patients [196 (52.4%)]. A predominance of gastro- intestinal reactions [70 (18.71%)] was observed. Therapeutic classes of drugs frequently associated with ADRs were antibiotics [84(22.4%)] followed by antihypertensive agents [63 (16.84%)] and antidiabetic [37 (9.89%)]. The most common drugs involved in causing ADRs were Furosemide and Cefoperazone and the most commonly reported ADR was Diarrhoea [28 (7.4.8%)] followed by Itching 2[9 (7.75%)]. Majority of the ADRs [95 (74.80%)] were managed by withdrawing the suspected drug. The causality assessment of the ADRs were carried out using the Naranjo’s Scale algorithm and the majority of the ADRs were found to be definite [41 (32%)]. Conclusion: Continuous monitoring by a clinical pharmacist in hospital setup will reduce the occurrence of ADR and improve the patient safety.
10aAdverse drug reaction10aCausality assessment10aNaranjo scale10aPatient safety10aPharmacovigilance1 aPriyanka, Pulimi, Divya1 aVithya, T.1 aHiremath, Shobha, Rani Rajee1 aPrasad, Shankar uhttps://jppcm.org/article/2020/6/1/15-17