Published on:February 2019
    Journal of Pharmacy Practice and Community Medicine, 2019; 5(1):3-12
    Review Article | doi:10.5530/jppcm.2019.1.2

    The Virulence of Helicobacter pylori Through CagA on Gastric Mucosa: A Review

    Authors and affiliation (s):

    Shida Hussain1, Zhang Li2, Xiaolan Lu2, Hamad Haider Khan3, Shi bingyin3, Faiz Ullah Khan4,5,6,8* Zakir Khan7, Beenish Ashfaq8, Inayat Ur Rehman9,10

    1Registrar Department of Nephrology Northwest General Hospital Hayatabad Peshawar, Pakistan, PAKISTAN.

    2Departmet of Gastroenterology Second affiliated hospital, Xi'an Jiaotong University, School of medicine, Shaanxi 710061, Xi'an, , CHINA.

    3Department of Clinical Endocrinology Xi’an Jiaotong University, First Affiliated Hospital, Xi’an, Shanxi, CHINA.

    4Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Centre, Xi’an Jiaotong University, CHINA.

    5Center for Drug Safety and Policy Research, Xi’an Jiaotong University, Xi’an, CHINA.

    6The Global Health Institute, Xi’an Jiaotong University, Xi’an, China; d Shaanxi Centre for Health Reform and Development Research, Xi’an, CHINA.

    7Department of Pharmacology, Institute of Health Sciences, Cukurova University, Adana,TURKEY.

    8Department of Pharmacy Quaid-i-Azam University Islamabad, PAKISTAN.

    9School of Pharmacy Monash University Malaysia Jalan Lagoon Selantan Bandar Sunway, MALAYSIA.

    10Department of Pharmacy, Abdul Wali Khan University, Mardan, PAKISTAN..


    Helicobacter pylori (H. pylori), is the most common infectious bacterium of the Human stomach. In early childhood, colonization of H. pylori in stomach releases different pathogenic factors which interfere with functions of human cells. Combination of two main genetic pathogenic factors CagA and VacA play important role in causing severity of H. pylori infection. In H. pylori infected patients, CagA and CagPAI positive strains have positive association in development of peptic ulcer disease and gastric cancers.50-70% of H. pylori produces CagA gene that is multifunction toxin. By adapting different mechanisms CagA define its role in oncogenic signaling cascades, in tumor suppressor pathway and in inflammation. CagA gene is strongly associated with VacA cytotoxic function and the strains, ultimately responsible for epithelial destruction of stomach and leading towards cancer. Review provides, CagA has important role in the virulence of H.pylori infection. Different Peptic ulcer diseases and gastric cancers are caused by the presence of CagA gene.

    Key words: H. pylori, CagA gene, VacA gene, Gastric cancers, Peptic ulcer disease.

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    Cite this article as

    Hussain S, Li Z, Lu X, Khan HH, bingyin S, Khan FU, et al. The Virulence of Helicobacter pylori Through CagA on Gastric Mucosa: A Review. Journal of Pharmacy Practice and Community Medicine. 2019;5(1):3-12. Abstract