Background: Gastro-esophageal Reflux disorder is return of the stomach's contents back up into the esophagus. Whereas diabetes is a metabolic disorder in which there is either no production of insulin or there is resistance to insulin being produced by body. Objectives: The aim of the systematic review is to study the pharmacotherapeutic consideration of GERD among elderly type 2 diabetes patients. Methods: This study analyzed 15 articles identified and selected according to the study criteria. PRISMA guidelines were used for identification and screening of literature. Data search covered several primary databases, including PubMed/MedLine, Wiley library, Scopus, Clinical Trial Registry, etc. Result and Findings: The data shows obese patients with BMI > 30kg/m2 with type 2 diabetes have higher chances of GERD. The findings also suggested increase in socioeconomic status shows increase incidence of type 2 diabetes mellitus with time and it also plays vital role to lifestyle modifications such as physical exercise e and dietary habits. The prevalence values of GERD by skipping breakfast, snacking during bedtime, late night eating and eating fast were 32.0%, 13.7%, 27.1%, 28.8% and 44.4%, respectively. Late night eating was independently positively associated with GERD in patients with type 2 diabetes; the adjusted odds ratio was 1.46 (95% CI 1.03 to 2.05). No relationships were found between not eating breakfast, snacking at bedtime or eating fast and GERD. Conclusion: The review findings suggested that patients with type 2 diabetes are at double risk of GERD as the metabolic disorder are making it worst. GERD can be avoided by minimizing the risk of type 2 diabetes either by controlling obesity by bariatric surgery or by exercise and more active lifestyle. There are some important considerations to decrease the incidence of GERD by evaluation and treatment in the older patients.
Key words: GERD, Geriatric, Diabetes Mellitus, Diet, Gastroenterology.