Vitamin D3 Analogues and Laboratory Tests Interactions: Public Health Awareness Glance

Journal of Pharmacy Practice and Community Medicine,2023,9,1,6.
Published:March 2023
Type:Letter to Editor
Author(s) affiliations:

Majid Khan1,*, Muhammad Riaz2, Muhammad Usman Amin1, Ashraf Ullah Khan1

1Faculty of Pharmaceutical Sciences, Abasyn University, Peshawar, Khyber Pakhtunkhwa, PAKISTAN.

2Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Upper Dir, Khyber Pakhtunkhwa, PAKISTAN.


Vitamin-D is available in the market in three different forms; cholecalciferol, alfacalcidol both of them are inactive and converted into active form calcitriol.[1] The conversion of both occurs by passing on liver hepatocytes by (25-hydroxylase) and kidneys (1-alfa-hydroxylase) while alfacalcidol is converted into active form only by the liver.[2,3] Thus, it means that those individuals whose Renal Function Tests (RFTs) and Liver Function Tests (LFTs) are raised they are unable to get benefits from cholecalciferol and those with raised LFTs will not get benefits from alfacalcidol thus the selection of choice in this condition will be calcitriol or 1, 25-dihydroxycholecalciferol is depicted in the (Figure 1).[4-6] To the best of our knowledge this will be the first attempt to highlight the selection of Vitamin D3 from different analogues. The main aim of this short comment to aware the public regarding the use of better alternative for the patients from the rest of three.